Region 4 or Region IV may refer to:
Government Region 4, Northwest Territories, a Statistics Canada census division Coquimbo Region, an administrative region of Chile which was historically named Region IV Southern Tagalog (designated as Region IV), an administrative region in the Philippines Calabarzon (designated as Region IV‑A), an administrative region in the Philippines Former Region 4 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006 One of the Regions of Iran
Technology DVD region 4, one of the DVD regions