Region 8 or Region VIII may refer to:
Government Former Region 8 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006 Eastern Visayas (designated as Region VIII), an administrative region in the Philippines
Technology DVD region 8, one of the DVD regions
Other uses KAIT, a television station located in Jonesboro, Arkansas branded as Region 8 NJCAA Region 8, a National Junior College Athletic Association region