Region 6 or Region VI may refer to:
Government East Berbice-Corentyne, Region 6 in Guyana Region 6, Northwest Territories, a Statistics Canada census division Former Region 6 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006 Western Visayas (designated as Region VI), an administrative region in the Philippines
Technology DVD region 6, one of the DVD regions
Other uses Region 6 War Room, a nuclear bunker in Reading