The Main River, more commonly simply the Main, is a river in Germany.

Main River, may also refer to: Main River (Chukotka), a river in far Eastern Siberia. Main River (Newfoundland), a river in Newfoundland, Canada. River Main (County Antrim), a river in Northern Ireland. Legislative Main river, a statutory designation of larger watercourses in England and Wales.

See also Maine River (disambiguation). Main (disambiguation).