Blood-group-substance endo-1,4-β-galactosidase (, endo-β-galactosidase, blood-group-substance 1,4-β-D-galactanohydrolase) is an enzyme with systematic name blood-group-substance 4-β-D-galactanohydrolase. It catalyses endohydrolysis of (1→4)-β-D-galactosidic linkages in blood group A and B substances.
It hydrolyses the 1,4-β-D-galactosyl linkages adjacent to a 1,3-α-D-galactosyl or N-acetylgalactosaminyl residues and a 1,2-α-D-fucosyl residue.
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