Keratan-sulfate endo-1,4-β-galactosidase (, endo-β-galactosidase, keratan sulfate endogalactosidase, keratanase, keratan-sulfate 1,4-β-D-galactanohydrolase) is an enzyme with systematic name keratan-sulfate 4-β-D-galactanohydrolase. It catalyses endohydrolysis of (1→4)-β-D-galactosidic linkages in keratan sulfate.
It hydrolyses the 1,4-β-D-galactosyl linkages adjacent to 1,3-N-acetyl-α-D-glucosaminyl residues.
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