TRNA (cytosine34-C5)-methyltransferase (, hTrm4 Mtase, hTrm4 methyltransferase, hTrm4 (gene), tRNA:m5C-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine34-C5)-methyltransferase. This enzyme catalyses the following chemical reaction
S-adenosyl-L-methionine + cytosine34 in tRNA precursor S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
The human enzyme is specific for C5-methylation of cytosine34 in tRNA precursors.
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