tRNA (cytosine38-C5)-methyltransferase (), is an enzyme involved in the methylation of transfer RNA which in humans is encoded by the gene TRDMT1 (previously DNMT2). Its systematic name is S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase. This enzyme catalyses the following chemical reaction:
S-adenosyl-L-methionine + cytosine38 in tRNA S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA
In particular, the eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC).
See also TRDMT1
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