N1-acetylpolyamine oxidase (, hPAO-1, mPAO, hPAO) is an enzyme with systematic name N1-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming). This enzyme catalyses the following chemical reaction
(1) N1-acetylspermidine + O2 + H2O putrescine + 3-acetamidopropanal + H2O2 (2) N1-acetylspermine + O2 + H2O spermidine + 3-acetamidopropanal + H2O2
This enzyme also catalyses the reaction: N1,N12-diacetylspermine + O2 + H2O N1-acetylspermidine + 3-acetamamidopropanal + H2O2.
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