The enzyme α,α-phosphotrehalase () catalyzes the following chemical reaction:
The enzyme characterised from Bacillus popilliae hydrolyses α,α-trehalose 6-phosphate to D-glucose 6-phosphate and D-glucose. Trehalose is an osmoprotectant and the enzyme regulates its level in organisms such as Clostridium perfringens. The enzyme has been used to assay levels of trehalose 6-phosphate.
This enzyme is a hydrolase, specifically a glycosidase that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is α,α-trehalose-6-phosphate phosphoglucohydrolase. This enzyme is also called phosphotrehalase.
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