The enzyme 3′(2′),5′-bisphosphate nucleotidase (EC 3.1.3.7) catalyzes several related reactions. For example, when characterised from guinea pig liver and Debaryomyces hansenii, it hydrolyses adenosine 3',5'-bisphosphat to adenosine monophosphate and orthophosphate:
It also hydrolyses 3'-phosphoadenosine-5'-phosphosulfate to 5'-adenylyl sulfate, which has a role in the incorporation of sulfate in metabolism.
This enzyme is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name is adenosine-3′(2′),5′-bisphosphate 3′(2′)-phosphohydrolase. Other names in common use include phosphoadenylate 3′-nucleotidase, 3′-phosphoadenylylsulfate 3′-phosphatase, and 3′(2′),5′-bisphosphonucleoside 3′(2′)-phosphohydrolase.
Structural studies As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , and .
References