3',5'-cyclic-GMP phosphodiesterase

The enzyme 3′,5′-cyclic-GMP phosphodiesterase (EC 3.1.4.35) catalyzes the reaction

The enzyme characterised from mice hydrolyses cyclic guanosine monophosphate (3',5'-cyclic GMP) to guanosine monophosphate. Unlike the enzyme cyclic nucleotide phosphodiesterase (EC 3.1.4.17) this reaction is specific to 3',5'-cyclic GMP.

This enzyme is a hydrolase, specifically one acting on phosphoric diester bonds. The systematic name is 3′,5′-cyclic-GMP 5'-nucleotidohydrolase. Other names in use include guanosine cyclic 3',5'-phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3′,5′-GMP phosphodiesterase, cyclic guanosine 3′,5′-monophosphate phosphodiesterase, cyclic guanosine 3′,5′-phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3′,5′-phosphate phosphodiesterase.

Structural studies As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes , , , , and .

References