In enzymology, an imidazoleacetate 4-monooxygenase () is an enzyme that catalyzes the chemical reaction
4-imidazoleacetate + NADH + H+ + O2 5-hydroxy-4-imidazoleacetate + NAD+ + H2O
The 4 substrates of this enzyme are 4-imidazoleacetate, NADH, H+, and O2, whereas its 3 products are 5-hydroxy-4-imidazoleacetate, NAD+, and H2O.
The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material. The systematic name of this enzyme class is 4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating). Other names in common use include imidazoleacetic hydroxylase, imidazoleacetate hydroxylase, and imidazoleacetic monooxygenase. This enzyme participates in histidine metabolism. It employs one cofactor, FAD.
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