Latia-luciferin monooxygenase (demethylating) () is an enzyme that catalyzes the chemical reaction

The reaction is an oxidation using molecular oxygen to cleave the formate ester of a luciferin found in the limpet Latia neritoides. The enzyme requires a reduced electron acceptor: light is emitted and carbon dioxide, water, and formic acid are produced as by-products.

This flavoprotein is an oxidoreductase with systematic name Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating). Other names in common use include luciferase (Latia luciferin), and Latia luciferin monooxygenase (demethylating).

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