Arquette is a surname. Notable people with the surname include:
Alexis Arquette (1969–2016), American transgender actress Cliff Arquette (1905–1974), American actor, father of Lewis David Arquette (born 1971), American actor Lewis Arquette (1935–2001), American actor, father of Alexis, David, Patricia, Richmond and Rosanna Patricia Arquette (born 1968), American actress Rosanna Arquette (born 1959), American actress
See also Arcouët