Siglo XXI (Spanish for 21st century) may refer to:
Media Diario Siglo XXI, a newspaper from the Valencian Community Siglo Veintiuno, a Guatemalan newspaper Siglo XXI, former name of the Argentine newspaper El Siglo, published in Tucumán Siglo XXI (publisher), a Spanish-language book publisher with business presences in Spain, Argentina, and Mexico
Other uses Auditorio Siglo XXI, in Puebla, Mexico Siglo XXI Convention Centre, in Mérida, Yucatán, Mexico Siglo XXI (Madrid Metro), a station on Line ML-3
See also 21st century (disambiguation)