Route 168, or Highway 168, may refer to:
Canada Prince Edward Island Route 168
Costa Rica National Route 168
Japan Japan National Route 168
Malaysia Malaysia Federal Route 168
United Kingdom road B168 road
United States U.S. Route 168 (former) Alabama State Route 168 Arkansas Highway 168 California State Route 168 Connecticut Route 168 Georgia State Route 168 Illinois Route 168 (former) Indiana State Road 168 K-168 (Kansas highway) Kentucky Route 168 Louisiana Highway 168 Maine State Route 168 Maryland Route 168 Massachusetts Route 168 M-168 (Michigan highway) Missouri Route 168 Nevada State Route 168 New Jersey Route 168 New York State Route 168 North Carolina Highway 168 Ohio State Route 168 Pennsylvania Route 168 South Dakota Highway 168 Tennessee State Route 168 Texas State Highway 168 Texas State Highway Loop 168 Farm to Market Road 168 Utah State Route 168 Virginia State Route 168 Washington State Route 168 Wisconsin Highway 168 Territories Puerto Rico Highway 168