Route 165, or Highway 165, may refer to:
Canada New Brunswick Route 165 Prince Edward Island Route 165 Quebec Route 165 Saskatchewan Highway 165 Winnipeg Route 165
Costa Rica National Route 165
India National Highway 165 (India)
Japan Japan National Route 165
United Kingdom road B165 road
United States Interstate 165 (disambiguation) U.S. Route 165 Alabama State Route 165 California State Route 165 Colorado State Highway 165 Connecticut Route 165 Florida State Road 165 (former) Georgia State Route 165 Illinois Route 165 Indiana State Road 165 Iowa Highway 165 Kentucky Route 165 Maryland Route 165 M-165 (Michigan highway) Minnesota State Highway 165 (former) Missouri Route 165 Nevada State Route 165 New Jersey Route 165 New Mexico State Road 165 New York State Route 165 Ohio State Route 165 Oklahoma State Highway 165 Rhode Island Route 165 South Carolina Highway 165 Tennessee State Route 165 Texas State Highway 165 Texas State Highway Spur 165 Ranch to Market Road 165 Utah State Route 165 Virginia State Route 165 Washington State Route 165 Wisconsin Highway 165
Territories:
Puerto Rico Highway 165 Puerto Rico Highway 165R