Margulies (occasionally Margolies or Margolyes) is a surname that, like its variants shown below, is derived from the Ashkenazi Hebrew pronunciation of the Hebrew word (), meaning 'pearls'. Notable people with the surname include:

Ben Margulies, American songwriter and record producer David Margulies (1937–2016), American actor Donald Margulies (born 1954), American playwright Jimmy Margulies (born 1951), American award-winning editorial cartoonist Joseph Margulies (artist) (1896–1984), Vienna-born American painter and printmaker Joseph Margulies (lawyer), American attorney and law professor Julianna Margulies (born 1966), American actress Lazar C. Margulies (1895–1982), physician and inventor of a type of Intrauterine device Leo Margulies (1900–1975), American editor and publisher Martin Margulies (born 1948), American musician/film producer better known as Johnny Legend Martin Margulies, real-estate developer and collector of contemporary art and photography Miriam Margolyes (born 1941), British-Australian actress Roni Margulies (1955–2023), Turkish poet and activist Samuel Hirsch Margulies (1858–1922), rabbi and Jewish scholar Susan Margulies, American engineer and professor

See also