Chromosome 17 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 17 spans more than 84 million base pairs (the building material of DNA) and represents between 2.5 and 3% of the total DNA in cells.

Chromosome 17 contains the Homeobox B gene cluster.

Genes Number of genes The following are some of the gene count estimates of human chromosome 17. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). The most conservative estimate, from CCDS, represents a lower bound on the total number of human protein-coding genes.

Estimated by Protein-coding genes Non-coding RNA genes Pseudogenes Source Release date CCDS 1,124 — — 2016-09-08 HGNC 1,137 404 495 2024-10-04 Ensembl 1,184 1,199 535 2017-03-29 UniProt 1,174 — — 2024-10-02 NCBI 1,199 757 566 2017-05-19

Gene list

The following is a partial list of genes on human chromosome 17. For complete list, see the link in the infobox on the right.

The following are some of the genes and their corresponding Cytogenetic location on chromosome 17:

p-arm

q-arm

Diseases and disorders

The following diseases are related to genes on chromosome 17:

17q12 microdeletion syndrome Koolen–de Vries syndrome Alexander disease Andersen–Tawil syndrome Aneurysmal bone cyst Bipolar disorder Birt–Hogg–Dubé syndrome Bladder cancer Breast cancer Bruck syndrome Campomelic dysplasia Canavan disease Cerebroretinal microangiopathy with calcifications and cysts Charcot–Marie–Tooth disease Chronic lymphocytic leukaemia, tp53 Corticobasal degeneration Cystinosis Depression Ehlers–Danlos syndrome Epidermodysplasia verruciformis Frontotemporal dementia and parkinsonism linked to chromosome 17 Galactosemia Glycogen storage disease type II (Pompe disease) Hereditary neuropathy with liability to pressure palsies Howel–Evans syndrome Li–Fraumeni syndrome Maturity onset diabetes of the young type 5 Miller–Dieker syndrome Multiple synostoses syndrome Neurofibromatosis type I Nonsyndromic deafness Obsessive–compulsive disorder Osteogenesis imperfecta Potocki–Lupski syndrome Proximal symphalangism Sanfilippo syndrome Smith–Magenis syndrome Usher syndrome Very long-chain acyl-coenzyme A dehydrogenase deficiency Von Gierke's syndrome

Cytogenetic band

+ G-bands of human chromosome 17 in resolution 850 bphsGenome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26. Chr. Arm"p": Short arm; "q": Long arm. BandFor cytogenetic banding nomenclature, see article locus. ISCNstartThese values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit. ISCNstop Basepairstart Basepairstop Staingpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk. Density 17 p 13.3 0 385 gneg 17 p 13.2 385 550 gpos 50 17 p 13.1 550 784 gneg 17 p 12 784 990 gpos 75 17 p 11.2 990 1499 gneg 17 p 11.1 1499 1664 acen 17 q 11.1 1664 1815 acen 17 q 11.2 1815 2104 gneg 17 q 12 2104 2255 gpos 50 17 q 21.1 2255 2461 gneg 17 q 21.2 2461 2599 gpos 25 17 q 21.31 2599 2874 gneg 17 q 21.32 2874 3025 gpos 25 17 q 21.33 3025 3176 gneg 17 q 22 3176 3383 gpos 75 17 q 23.1 3383 3451 gneg 17 q 23.2 3451 3658 gpos 75 17 q 23.3 3658 3781 gneg 17 q 24.1 3781 3850 gpos 50 17 q 24.2 3850 4001 gneg 17 q 24.3 4001 4166 gpos 75 17 q 25.1 4166 4400 gneg 17 q 25.2 4400 4510 gpos 25 17 q 25.3 4510 4950 gneg

References

Gene Card Website https://www.genecards.org/cgi-bin/carddisp.pl?gene=SCN4A

External links