Chromosome 16 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 16 spans about 90 million base pairs (the building material of DNA) and represents just under 3% of the total DNA in cells.
Genes Number of genes The following are some of the gene count estimates of human chromosome 16. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.
Estimated by Protein-coding genes Non-coding RNA genes Pseudogenes Source Release date CCDS 795 — — 2016-09-08 HGNC 802 251 365 2017-05-12 Ensembl 865 1,046 462 2017-03-29 UniProt 838 — — 2018-02-28 NCBI 912 652 502 2017-05-19
Gene list
The following is a partial list of genes on human chromosome 16. For complete list, see the link in the infobox on the right.
Diseases and disorders Attention deficit hyperactivity disorder (ADHD) Asperger syndrome Autism spectrum disorder Autosomal dominant polycystic kidney disease (PKD-1) Batten disease Combined malonic and methylmalonic aciduria (CMAMMA) Familial Mediterranean fever (FMF) Synesthesia Thalassemia Trisomy 16 Morquio syndrome Hao-Fountain Syndrome
Associated traits Red hair
Cytogenetic band
+ G-bands of human chromosome 16 in resolution 850 bphsGenome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26. Chr. Arm"p": Short arm; "q": Long arm. BandFor cytogenetic banding nomenclature, see article locus. ISCNstartThese values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit. ISCNstop Basepairstart Basepairstop Staingpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk. Density 16 p 13.3 0 352 gneg 16 p 13.2 352 596 gpos 50 16 p 13.13 596 813 gneg 16 p 13.12 813 948 gpos 50 16 p 13.11 948 1070 gneg 16 p 12.3 1070 1246 gpos 50 16 p 12.2 1246 1409 gneg 16 p 12.1 1409 1558 gpos 50 16 p 11.2 1558 1856 gneg 16 p 11.1 1856 2045 acen 16 q 11.1 2045 2194 acen 16 q 11.2 2194 2709 gvar 16 q 12.1 2709 2953 gneg 16 q 12.2 2953 3142 gpos 50 16 q 13 3142 3346 gneg 16 q 21 3346 3657 gpos 100 16 q 22.1 3657 4023 gneg 16 q 22.2 4023 4118 gpos 50 16 q 22.3 4118 4294 gneg 16 q 23.1 4294 4551 gpos 75 16 q 23.2 4551 4659 gneg 16 q 23.3 4659 4768 gpos 50 16 q 24.1 4768 4930 gneg 16 q 24.2 4930 5025 gpos 25 16 q 24.3 5025 5120 gneg
References
In http://omim.org/search?index=geneMap&search=16p13.3
External links