Chromosome 10 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 10 spans about 134 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells.

Genes Number of genes The following are some of the gene count estimates of human chromosome 10. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.

Estimated by Protein-coding genes Non-coding RNA genes Pseudogenes Source Release date CCDS 706 — — 2016-09-08 HGNC 708 244 614 2017-05-12 Ensembl 728 881 568 2017-03-29 UniProt 750 — — 2018-02-28 NCBI 754 842 654 2017-05-19

Gene list

The following is a partial list of genes on human chromosome 10. For complete list, see the link in the infobox on the right.

Diseases and disorders The following diseases are related to genes on chromosome 10:

Apert syndrome Barakat syndrome Beare–Stevenson cutis gyrata syndrome Charcot–Marie–Tooth disease Cockayne syndrome Congenital erythropoietic porphyria Cowden syndrome Crouzon syndrome Genitopatellar syndrome Glioblastoma multiforme Gorlin syndrome HADDS syndrome Hermansky–Pudlak syndrome Hirschprung disease Jackson–Weiss syndrome Multiple endocrine neoplasia type 2 Nonsyndromic deafness Pfeiffer syndrome Porphyria Sphingosine phosphate lyase insufficiency syndrome Spondyloepimetaphyseal dysplasia, Pakistani type Tetrahydrobiopterin deficiency Thiel–Behnke corneal dystrophy Usher syndrome Wolman syndrome Young-Simpson syndrome Combined Saposin Deficiency

Cytogenetic band

+ G-bands of human chromosome 10 in resolution 850 bphsGenome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26. Chr. Arm"p": Short arm; "q": Long arm. BandFor cytogenetic banding nomenclature, see article locus. ISCNstartThese values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit. ISCNstop Basepairstart Basepairstop Staingpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk. Density 10 p 15.3 0 229 gneg 10 p 15.2 229 329 gpos 25 10 p 15.1 329 630 gneg 10 p 14 630 917 gpos 75 10 p 13 917 1175 gneg 10 p 12.33 1175 1361 gpos 75 10 p 12.32 1361 1432 gneg 10 p 12.31 1432 1604 gpos 75 10 p 12.2 1604 1662 gneg 10 p 12.1 1662 1891 gpos 50 10 p 11.23 1891 2063 gneg 10 p 11.22 2063 2235 gpos 25 10 p 11.21 2235 2406 gneg 10 p 11.1 2406 2621 acen 10 q 11.1 2621 2850 acen 10 q 11.21 2850 3051 gneg 10 q 11.22 3051 3252 gpos 25 10 q 11.23 3252 3409 gneg 10 q 21.1 3409 3753 gpos 100 10 q 21.2 3753 3839 gneg 10 q 21.3 3839 4097 gpos 100 10 q 22.1 4097 4469 gneg 10 q 22.2 4469 4655 gpos 50 10 q 22.3 4655 4970 gneg 10 q 23.1 4970 5200 gpos 100 10 q 23.2 5200 5331 gneg 10 q 23.31 5331 5558 gpos 75 10 q 23.32 5558 5672 gneg 10 q 23.33 5672 5887 gpos 50 10 q 24.1 5887 5973 gneg 10 q 24.2 5973 6131 gpos 50 10 q 24.31 6131 6202 gneg 10 q 24.32 6202 6317 gpos 25 10 q 24.33 6317 6374 gneg 10 q 25.1 6374 6646 gpos 100 10 q 25.2 6646 6761 gneg 10 q 25.3 6761 6890 gpos 75 10 q 26.11 6890 7090 gneg 10 q 26.12 7090 7219 gpos 50 10 q 26.13 7219 7506 gneg 10 q 26.2 7506 7721 gpos 50 10 q 26.3 7721 8050 gneg

References

External links