Charles-Antoine is a masculine given name. Notable people with the name include:

Charles-Antoine Bridan, French sculptor Charles-Antoine Leclerc de La Bruère, French historian and diplomat Charles-Antoine Cambon, French scenographer Charles-Antoine Campion, French-Italian composer Charles-Antoine Clevenbergh, Flemish still life painter Charles-Antoine Coypel, French painter, art critic, and playwright Charles-Antoine Jombert, French bookseller and publisher Charles-Antoine Hérault, French landscape painter Charles-Antoine Kouakou (born 1998), French Paralympic athlete Charles-Antoine Lamoral, French-born businessman Charles-Antoine Rochat, French diplomat

See also Antoine-Charles, masculine given name Charles-Antoine-Ernest Gagnon, notary and politician in Quebec