Marie-Alphonse is a masculine compound given name which may refer to:
Marie-Alphonse Ratisbonne (1812–1884), French Jew who converted to Christianity, Jesuit priest and missionary, co-founder of the Congregation of Our Lady of Sion Marie-Alphonse Dain (1896–1964), French Hellenist and Byzantinist Marie-Alphonse Sonnois (1828–1913), French Catholic bishop and archbishop
See also Marie Alphonse Bedeau (1804–1863), French general and minister Alphonse-Marie, another given name