Marie-Paule is a feminine compound given name which may refer to:
Marie-Paule Blé (born 1998), French taekwondo practitioner Marie-Paule Cani (born 1965), French computer scientist Marie-Paule Alice Courbe (1845–1894), pseudonym Gisèle d'Estoc, French writer, sculptor and feminist Marie-Paule Foppossi (born 1998), French basketball player Marie-Paule Gnabouyou (born 1988), French handball player Marie-Paule Kieny (born 1955), French virologist and science writer Marie-Paule Malliavin (1935–2019), French mathematician Marie-Paule Miller (born 1968), French deaf sprinter and heptathlete Marie-Paule Pileni (born 1945), French physical chemist Marie-Paule Serve (born 1941), New Caledonian politician Marie-Paule Van Eyck (born 1951), Belgian fencer