Marie-Dominique is a unisex compound given name which may refer to:
Marie-Do Aeschlimann (born 1974), French politician Marie-Dominique Chenu (1895–1990), French priest and theologian Marie-Dominique Lelièvre, French writer and journalist Marie-Dominique Philippe (1912–2006), French philosopher and theologian
See also Marie Dominique Luizet (1852–1930), French botanist and chemist