Msomi is a surname. Notable people with the surname include:
Bongani Msomi, South African politician Bongiwe Msomi (born 1988), South Africa netball player and coach Elifasi Msomi (1910–1956), South African serial killer Mandla Msomi (born 1950), South African politician and businessman Sibusiso Msomi (born 1988), South African footballer Welcome Msomi (1943–2020), South African playwright, actor, and writer