Matambanadzo is a surname. Notable people with the surname include:
Darlington Matambanadzo (born 1976), Zimbabwean cricketer Everton Matambanadzo (born 1976), Zimbabwean cricketer Isabella Matambanadzo (born 1973), Zimbabwean writer, gender and feminist activist Masango Matambanadzo (1964–2020), Zimbabwean politician