Mashayekhi is a surname. Notable people with the surname include:
Afsaneh Mashayekhi Beschloss (born 1956), American economist and entrepreneur Alireza Mashayekhi (born 1940), Iranian musician, composer, conductor and academic Gisela Mashayekhi-Beer (born before 1966), Austrian flautist and professor Jamshid Mashayekhi (1934–2019), Iranian actor Nader Mashayekhi (born 1958), Iranian composer Sajjad Mashayekhi (born 1994), Iranian basketball player