Mutius is the surname of a historical German noble family ().
Notable people with the surname include: Franz Josef von Mutius (1704–1788), court and judicial councillor, chancellor of the cathedral chapter in Breslau, ennobled 1745 Johann Karl von Mutius (1758–1816), Prussian major general Louis von Mutius (1796–1866), Prussian cavalry general Peter von Mutius (1828–1904), Prussian major general Wilhelm von Mutius (1832–1918), Prussian lieutenant general Albert von Mutius (1862–1937), Prussian lieutenant general Maximilian von Mutius (1865–1942), Prussian major general Gerhard von Mutius (1872–1934), diplomat Theodor von Mutius (1909–1977), German flotilla admiral Gerta Scharffenorth, née von Mutius (1912), political scientist and theologian Bernhard Ludwig von Mutius (1913–1979), secretary of the German People's Congress Albrecht von Mutius (1915–1985), Protestant theologian Carl von Mutius (1918), officer and press officer in the German UN mission in Geneva Dagmar von Mutius (1919–2008), German writer Franz von Mutius (1925–2011), administrative lawyer Albert von Mutius (1942), legal scholar Bernhard von Mutius (1949), philosopher and social scientist Hans-Georg von Mutius (1951), Judaist Erika von Mutius (born 1957), German pediatrician