Gbadegesin is a surname. Notable people with the surname include:

Tariye Gbadegesin, Nigerian-American businesswoman Adeniyi Sulaimon Gbadegesin (born 1958), Nigerian academic Sàngódáre Gbádégesin Àjàlá (1948–2021), Nigerian artist Ajibade Gbadegesin Ogunoye III (born 1966), Nigerian ruler