Gunasena is a given name and surname. Notable people with the name include:
Gunasena (850–900), Indian monk Gunasena de Soyza (1902–1961), Sri Lankan civil servant Gunasena Galappatty (born 1927), Sri Lankan dramatist Prasanna Gunasena (), Sri Lankan neurosurgeon Don Gunasena Athukorala (1924–2024), Sri Lankan civil engineer