Mergui is a surname. Notable people with the surname include:
Joël Mergui (born 1958), French physician and Jewish official Jonathan Mergui (born 2000), Israeli singer, actor and dancer
See also Myeik, Myanmar, formerly known as Mergui, a rural city in Tanintharyi Region, Myanmar Mergui Archipelago, an island chain off the coast of Tanintharyi Region, Myanmar Mergui Road, a former transit route between Myanmar and Thailand