Calatayud or de Calatayud is a surname of Spanish origin. Notable people with the surname include:
Alejo Calatayud ( 1705–1731), Mestizo silversmith and rebel leader Alexis Calatayud ( 2018–present), American politician Bartolomé Calatayud (1882–1973), Spanish guitar composer Cala (footballer, born 1990) (full name Sergio Calatayud Lebrón), Spanish footballer Celedonio Calatayud (1880–1931), Spanish scientist and radiologist Juan Calatayud (born 1979), Spanish footballer Martín de Calatayud (1501–1548), Spanish Roman Catholic bishop Pedro de Calatayud (1689–1773), Spanish Jesuit missionary Santiago Calatayud (died 1526), Roman Catholic bishop Zulia Calatayud (born 1979), Cuban runner
See also Calatayud, a city in Zaragoza, Spain