Lorenzo Musetti defeated Matteo Berrettini in the final, 7–6(7–5), 6–2 to win the singles tennis title at the 2022 Napoli Cup. It was his second career ATP Tour singles title.
Tallon Griekspoor was the reigning champion from 2021, when the tournament was an ATP Challenger Tour event, but chose to compete in Antwerp instead.
Seeds The top four seeds received a bye into the second round.
Draw
Finals
Top half
Bottom half
Qualifying Seeds
Qualifiers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
References
External links Main draw Qualifying draw