Jessica Pegula defeated Maria Sakkari in the final, 6–2, 6–3 to win the women's singles tennis title at the 2022 Guadalajara Open. Pegula defeated four major champions in succession en route to her first WTA 1000 title, and she saved three match points en route, in her second-round match against Elena Rybakina.
This was the first time that Guadalajara hosted a WTA 1000-level event, having hosted the previous year's WTA Finals.
Seeds The top eight seeds received a bye into the second round.
Draw
Finals
Top half Section 1
Section 2
Bottom half Section 3
Section 4
Qualifying Seeds
Qualifiers
Lucky losers
Draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
Eighth qualifier
References
External links Qualifying draw Main draw