Santo Domingo Cathedral may refer to: Basilica Cathedral of Santa María la Menor, Santo Domingo, Dominican Republic Episcopal Cathedral of the Epiphany-Union Church of Santo Domingo, Dominican Republic Cathedral of the Roman Catholic Diocese of Santo Domingo in Ecuador Cobán Cathedral (Catedral de Santo Domingo de Guzmán), Guatemala Basco Cathedral, Philippines, also known as Santo Domingo Bayombong Cathedral (Santo Domingo de Guzman Cathedral), Nueva Vizcaya, Philippines Santo Domingo de la Calzada Cathedral, Spain