John McEnroe and Mary Carillo were the defending champions but both players chose not to participate.
Virginia Ruzici, the winner of the women's singles and the women's doubles titles, reached the mixed doubles final, which she lost to Pavel Složil and Renáta Tomanová when her partner Patrice Dominguez retired with an injury.
Draw
Finals
Top half
Bottom half
References
External links 1978 French Open – Doubles draws and results at the International Tennis Federation