Spottiswoode, also Spottiswood, is a surname of Scottish origin. It was first used by Robert de Spottiswoode and his descendants.

Notable people with the surname include:

Alicia Ann Spottiswoode (1810–1900), Scottish songwriter Andrew Spottiswoode (1787–1866), British politician Frank Spottiswoode, English professional rugby league footballer of the 1900s Frank Spottiswoode Aitken (1868–1933), Scottish-American silent film actor James Spottiswood (1567-1645), Scottish bishop, 2nd son of next John Spottiswood (1510-1585), religious reformer John Spottiswoode (1565–1633), Archbishop of St Andrews, elder son of prec. Jonathan Spottiswoode (born 1964), British musician, writer, and filmmaker Roger Spottiswoode (born 1945), Canadian-British film director and screenwriter William Spottiswoode, FRS (1825–1883), English mathematician and physicist, son of Andrew

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