Ann or Anne Clarke may refer to:
Ann Clarke (artist) (born 1944), Canadian artist Ann Clarke (immunologist), co-founder in 2004 of the Frozen Ark project Anne Clarke (theatre producer) (born 1961), Irish theatre producer Anne Clarke (theatre manager) (1806–?), Australian stage actor, singer and theatre manager Nancy Clarke (entrepreneur) (died 1811/12), also Ann, Barbadian hotelier and free woman of colour Anne Clarke (archaeologist), Australian archaeologist Ann M. Clarke (1928–2015), developmental psychologist Anne Clarke (politician), American-born British politician from London
See also Anne Clark (disambiguation) Anna Clarke (1919–2004), British author of mystery novels Anna Mac Clarke (1919–1944), Women's Army Corps officer Anna Maria Catherine Clarke (c. 1789–1817), British heiress