Sarles is a surname. Notable people with the surname include:
Bob Sarles (born 1957), American filmmaker Elmore Y. Sarles (1859–1929), American politician Nathalie Sarles (born 1962), French politician Roscoe Sarles (1892–1922), American racecar driver Ruth Sarles Benedict (1906–1996), American journalist William Bowen Sarles (1906–1987), American microbiologist