Wetzler is a surname. Notable people with the name include:
Alfréd Wetzler (1918–1988), Austro-Hungarian writer Ben Wetzler (born 1991), American baseball pitcher Gwen Wetzler, American producer, director and animator
See also Wetzler Symphony Orchestra, American orchestra Vrba–Wetzler report, is a 40-page document about the Auschwitz concentration camp in German-occupied Poland during the Holocaust