Holliday Creek is a stream in Wayne County in the U.S. state of Missouri. It is a tributary to the St. Francis River within Lake Wappapello.
The stream headwaters arise north of Missouri Route E west of the community of Burbank at . The stream flows southwest passing southeast of Greenville and enters the waters of Lake Wappapello. The confluence with the St. Francis prior to the lake formation was just southeast of the US Route 67 bridge at .Greenville, Missouri, 7.5 Minute Topographic Quadrangle, USGS, 1966 (1985 rev.)Greenville SW, Missouri, 7.5 Minute Topographic Quadrangle, USGS, 1966 (1976 rev.)Greenville, Missouri, 15 Minute Topographic Quadrangle, USGS, 1934
Holliday Creek has the name of Hiram Holliday, a businessperson in the local lumber industry.
See also List of rivers of Missouri
References