Hubble Creek is a stream in Wayne County in the U.S. state of Missouri. It is a tributary of the St. Francis River.
The stream headwaters arise at and the stream flows south-southwest parallel to US Route 67 passing the communities of Bounds and Silva to its confluence with the St. Francis within the waters of Lake Wappapello at .Greenville, Missouri, 7.5 Minute Topographic Quadrangle, USGS, 1966 (1985 rev.)
Hubble Creek has the name of a pioneer citizen.
See also List of rivers of Missouri Hubble Creek, Cape Girardeau County
References