Louse Creek is a stream in southern Oregon County in the Ozarks of southern Missouri. It is a tributary of Frederick Creek.

The stream headwaters are at and the confluence with Frederick Creek is at . The stream source area lies north of Missouri Route 142 and it flows northeast crossing under Missouri Route E and joins Frederick Creek east of Garfield.Myrtle, Missouri, 7.5 Minute Topographic Quadrangle, USGS, 1984Missouri Atlas & Gazetteer, DeLorme, 1998, First edition, p. 65,

Louse Creek was so named on account of the poor hygiene of the locals near its course.

See also List of rivers of Missouri

References