Low Wassie Creek is a stream in northern Oregon County in the Ozarks of southern Missouri.
The stream headwaters are at and the confluence with Spring Creek is at .Piedmont Hollow, Missouri, 7.5 Minute Topographic Quadrangle, USGS, 1982
Low Wassie Creek derives its name from the extinct community of Hiwassie.
See also List of rivers of Missouri
References