Bruzzone is an Italian surname. Notable people with the surname include:
Félix Bruzzone (born 1976), Argentinian writer Francesco Bruzzone (born 1962), Italian politician Mario Bruzzone (1887–1940), Italian sailor Nicolás Bruzzone (born 1985), Argentine rugby sevens player Rodolfo Bruzzone (1901–?), Argentine soccer player Tiziano Bruzzone (born 1984), Italian footballer