Mamba is a surname. Notable people with the surname include:
Alberto Mamba (born 1994), Mozambican middle-distance runner Manuel Mamba (born 1958), Filipino politician Mzwandile Mamba (born 1981), Swazi politician Ndumiso Mamba, Swazi government minister Priscilla Mamba (born 1972), Swazi long-distance runner Virginie Mamba (born 1980), Democratic Republic of the Congo handball player
See also Hugo Mamba-Schlick (born 1982), Cameroonian triple jumper