De la Sota is a Spanish surname. Notable people with the surname include:
Alejandro de la Sota, several people Imanol de la Sota (born 1975), Spanish football manager José Manuel de la Sota (1949–2018), Argentine politician Manuel de la Sota (1897–1979), Basque writer Natalia de la Sota (born 1975), Argentine politician Ramon de la Sota (1857–1936), Basque lawyer and industrialist
See also Calle Daniel de la Sota Sota (surname)