Substituted phenylmorpholines, or substituted phenmetrazines alternatively, are chemical derivatives of 2-phenylmorpholine or of the psychostimulant drug phenmetrazine.
Most such compounds act as releasers of monoamine neurotransmitters, and have stimulant effects. Some also act as agonists at serotonin receptors, and compounds with an N-propyl substitution act as dopamine receptor agonists.
A number of derivatives from this class have been investigated for medical applications, such as for use as anorectics or medications for the treatment of ADHD. Some compounds have also become subject to illicit use as designer drugs.
List of phenylmorpholines
+ List of phenmetrazine analogues and related compounds Substance Structure CAS # 2-phenylmorpholine 23972-41-04-phenylmorpholine 92-53-5 2-phenyl-3-methylmorpholine (phenmetrazine) 134-49-6 2-phenyl-3,4-dimethylmorpholine (phendimetrazine) 634-03-7 2-phenyl-5-methylmorpholine (isophenmetrazine) 80123-66-6 2-phenyl-3-ethylmorpholine (phenetrazine) 100368-98-7 2-phenyl-3-methyl-4-ethylmorpholine (phenmetetrazine) 92196-09-3 2-phenyl-3,5-dimethylmorpholine (PDM-35) 1218345-44-8 2-phenyl-3,6-dimethylmorpholine (6-methylphenmetrazine, 3,6-DMPM) 92902-99-3 2-phenyl-5,5-dimethylmorpholine (G-130) 42013-48-9 2-phenyl-3-methylmorpholin-5-one (fenmetramide) 5588-29-4 4-isopropyl-2-phenylmorpholineChem-Sink (chemicals that are Sn2 products & Friedel-Crafts alkylation reactants) 23222-62-0 Fenbutrazate 4378-36-3 Morazone 6536-18-1 2-Fluorophenmetrazine 1533654-24-8 3-fluorophenmetrazine (PAL-593) 1350768-28-3 4-Fluorophenmetrazine (PAL-748) 1097796-73-0 3-fluorophenetrazine 3-chlorophenmetrazine (PAL-594) 1097796-78-5 3-Methoxyphenmetrazine 2-Methylphenmetrazine 1507705-48-7 3-methylphenmetrazine (PAL-773) 1350768-41-0 4-methylphenmetrazine (PAL-747) 1998216-41-3 4-methylphendimetrazine 1445576-23-7 3-Iodophenmetrazine 2-(4-Bromo-2,5-dimethoxyphenyl)morpholine (2C-B-morpholine) 3,4-Methylenedioxyphenmetrazine Naphthylmetrazine (PAL-704) 2-(thiophen-2-yl)-3-methylmorpholine 2-(3-(Trifluoromethyl)phenyl)morpholine (flumexadol)Chemicalbook dot com: Flumexadol 30914-89-7 Oxaflozane 26629-87-8 Phenmetrazol 1350768-19-2 N-Ethylphenmetrazol 97630-98-3 (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol (radafaxine) 106083-71-0 (2S,3S,5R)-2-(3,5-difluorophenyl)-3,5-dimethylmorpholin-2-ol (manifaxine) 135306-39-7 PF-219,061Morpholine Dopamine Agonists For The Treatment Of Pain. Michael Andrew Ackley US 2009/0318451 AI Dec., 24th 2009. 1st Page. 710654-74-3 PF-592,379 710655-15-5 OSU-6162 156907-84-5 LPH-5Kristensen J, et al. 5-HT2A Agonists for Use in Treatment of Depression. Patent US 2021/0137908 2641630-97-7 2-Methyl-3-phenylpiperidine 70769-67-4 2-Phenyl-3-methyl-thiomorpholine 4-Methyl-5-phenyl-1,3-oxazolidine 42794-92-3 Picilorex 62510-56-9 Butyltolylquinuclidine 3-benzylmorpholine (3-BZM)NIH PubChem Compound Summary for CID 3283983 7684-27-7 3-Benzhydrylmorpholine (3-BZHM) 93406-27-0
Additional phenylmorpholines and their activities as monoamine releasing agents (MRAs) have been described.
See also Substituted amphetamine Substituted benzofuran Substituted cathinone Substituted methylenedioxyphenethylamine List of aminorex analogues List of methylphenidate analogues List of phenyltropanes List of cocaine analogues
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